Mediastinal Grey Zone Lymphoma From the LYSA

Civil Hospices of Lyon

Status: Completed

Conditions: Mediastinal Grey Zone Lymphoma

Study type: Observational

Funder types: Other

Identifiers

NCT03037177

69HCL16_0721

Details and patient eligibility

About

Mediastinal grey zone lymphoma, B cell lymphomas with intermediate features between classical Hodgkin lymphoma and primary mediastinal B cell lymphoma, are not well described in the literature. Investigators report the clinical characteristics and outcomes of a large retrospective series of 99 cases centrally reviewed by a panel of hematopathologists, with a consensus established for the diagnosis.

Enrollment: 99 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• cases with an intermediate morphology and phenotype between CHL and PMBCL were included after central pathological review

Exclusion criteria

• Cases of CHL with partial CD20 expression or low expression in tumoral cells were excluded and considered as CD20-positive CHL
• Exclusion of sequential form patients (with a diagnostic biopsy of PMBCL and a relapse biopsy of CHL or vise-versa) as they represent a biases for statistical analysis.

Trial design

99 participants in 3 patient groups

CHL like GZL

Description:

Classical Hodgkin Lymphoma like Grey Zone Lymphoma (morphology of CHL and phenotype of PMBCL)

PMBCL like GZL

Description:

Primary Mediastinal B Cell Lymphoma like Grey Zone Lymphoma(morphology of PMBCL and phenotype of CHL)

Composite

Description:

with a morphology of CHL on the one side and of PMBCL on the other side of the same diagnosis biopsy