Mediastinal Staging of Lung Cancer With EBUS-TBNA and EUS-B-FNA

National Cancer Center (NCC)

Status: Completed

Conditions: Lung Cancer

Treatments: Procedure: EBUS-TBNA, EUS-B-FNA (EUS-FNA with bronchoscope)

Study type: Interventional

Funder types: Other

Identifiers

NCT00741247

NCCCTS-08-332

Details and patient eligibility

About

The purpose of this study is to find a role of EUS-B-FNA in the mediastinal staging of potentially operable lung cancer. The investigators perform EBUS-TBNA and EUS-B-FNA on potentially operable lung cancer patients. The investigators perform EBUS(+/- TBNA) and EUS-B (ultrasonographic examination through the esophagus) on all subjects. EUS-B-FNA will be performed on inaccessible nodes or difficult nodes to be sampled by EBUS-TBNA. Additional diagnostic values of EUS-B-FNA as compared to EBUS-TBNA alone will be estimated.

Enrollment: 150 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed or strongly suspected potentially operable non-small cell lung cancer (NSCLC)
• Potentially operable patients

Exclusion criteria

After staging work-up for NSCLC, including bronchoscopy,CT of the chest and upper abdomen, integrated PET/CT and brain MRI (and/or bone scan)

• M1 disease
• Inoperable T4 disease
• Mediastinal infiltration or extranodal invasion of the mediastinal lymph node visible on chest CT.
• Confirmed supraclavicular lymph node metastasis
• Pancoast tumors
• Medically inoperable patients
• Contraindications for bronchoscopy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)