Mediation Analysis in Cardiac Surgery (MACS)

Zhejiang University

Status: Completed

Conditions: Anemia; Cardiac Surgery; Mediation; Transfusion

Treatments: Other: nonanemia; Other: anemia

Study type: Observational

Funder types: Other

Identifiers

NCT07092683

20210655

Details and patient eligibility

About

This study investigates the mediating role of intraoperative allogeneic red blood cell transfusion in the relationship between preoperative anaemia and postoperative complications in patients undergoing cardiac surgery. Using mediation analysis methods, we aim to determine whether and to what extent intraoperative transfusion explains the association between preoperative anaemia and adverse postoperative outcomes. By elucidating this pathway, the study seeks to inform perioperative blood management strategies and support more personalized, risk-adapted approaches to minimize postoperative complications in anaemic patients undergoing cardiac procedures.

Enrollment: 5,883 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18 and older ；
• Undergoing elective cardiac surgery with cardiopulmonary bypass

Exclusion criteria

• preoperative mechanical circulatory support
• ASA physical status VI-V
• unplanned intra-hospital reoperations
• catheter-based valve replacements,
• heart tumours,
• stent implantation surgeries,
• coronary angiography,
• transvascular valve clamping,
• tetralogy of Fallot,
• ventricular aneurysms,
• cardiomyopathies,
• transfusion thresholds above 8 g/dL

Trial design

5,883 participants in 2 patient groups

anemia

Treatment:

Other: anemia

nonanemia

Treatment:

Other: nonanemia