Medical and Physiological Benefits of Reduced Sitting

Turku University Hospital (TYKS)

Status

Completed

Conditions

Physical Activity

Insulin Resistance

Cardiovascular Diseases

Metabolic Syndrome

Treatments

Behavioral: Reduced sitting

Study type

Interventional

Funder types

Other

Identifiers

NCT03101228

T91/2017

Details and patient eligibility

About

The most important objective of this randomized controlled trial in subjects with increased cardiovascular and metabolic risk factors is to investigate whether only reduced daily sitting improves human cardiovascular and metabolic health during a six-month intervention. It is hypothesized and expected that only reduced sitting, without formal physical activity or exercise training, affects favorably cardiovascular and metabolic health.

Enrollment

64 patients

Sex

All

Ages

40 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Physically inactive (less than 120 minutes of moderate intensity exercise per week measured by the activity monitor during run-in)
Sitting time ≥ 10 h /day (measured by the activity monitor during run-in)
BMI 25-40
Blood pressure < 160/100 mmHg
Fasting plasma glucose < 7.0 mmol/l
Fulfills the criteria of the metabolic syndrome according to Alberti et al 2009

Exclusion criteria

History of a cardiac event
Insulin or medically treated diabetes
Any chronic disease or condition that could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
Presence of ferromagnetic objects that would make MR imaging contraindicated
Abundant use of alcohol
Use of narcotics
Smoking of tobacco or consuming snuff tobacco
Diagnosed depressive or bipolar disorder
Previous PET imaging or considerable exposure to radiation