Medical and Psychosocial Issues in Adolescents and Young Adults With Colorectal Cancer

University of Southern California

Status

Active, not recruiting

Conditions

Stage IVC Colorectal Cancer AJCC v8

Stage IIA Colorectal Cancer AJCC v8

Stage IIC Colorectal Cancer AJCC v8

Stage IVA Colorectal Cancer AJCC v8

Stage IIIA Colorectal Cancer AJCC v8

Stage IIIB Colorectal Cancer AJCC v8

Stage II Colorectal Cancer AJCC v8

Stage IVB Colorectal Cancer AJCC v8

Stage IIB Colorectal Cancer AJCC v8

Stage IIIC Colorectal Cancer AJCC v8

Stage IV Colorectal Cancer AJCC v8

Stage I Colorectal Cancer AJCC v8

Stage III Colorectal Cancer AJCC v8

Treatments

Other: Quality-of-Life Assessment

Other: Physical Performance Testing

Procedure: Biospecimen Collection

Other: Medical Chart Review

Other: Questionnaire Administration

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT04832763

NCI-2020-02581 (Registry Identifier)

P30CA014089 (U.S. NIH Grant/Contract)

3C-19-4 (Other Identifier)

Details and patient eligibility

About

This study investigates the medical and psychosocial consequences of colorectal cancer on adolescents and young adults. Measuring physical function in adolescents and young adults with colorectal cancer may help doctors better understand the level of physical function during cancer treatment and how to improve the management of colorectal cancer in adolescents and young adults. This study may also help design a future exercise program to decrease risk factors including high blood pressure, high blood sugar, and high cholesterol.

Full description

PRIMARY OBJECTIVES:

I. To prospectively characterize the symptom burden and assess the health-related quality of life of adolescents and young adults (AYAs) in active treatment for colorectal cancer in comparison to older patients to identify differences that contribute to the development of appropriately timed, age appropriate interventions.

II. To characterize the symptom burden and assess the health-related quality of life of AYAs who have completed curative therapy and are in surveillance for colorectal cancer compared to older patients to identify differences that contribute to the development of appropriately timed, age-appropriate interventions.

SECONDARY OBJECTIVE:

I. Using a prospective and cross-sectional design, characterize physical function, body composition, and biomarkers of comorbid conditions among AYAs with colorectal cancer (CRC) on active therapy and after completion of therapy in survivorship to identify targets for and timing of interventions.

EXPLORATORY OBJECTIVE:

I. To assess across Aims differences by cancer site (colon versus [vs.] rectal) by sex, and by race/ethnicity.

OUTLINE:

Patients on active treatment complete questionnaires and undergo collection of blood samples and physical function assessments at baseline, and at 3 and 6 months. Survivors in surveillance complete questionnaires and undergo collection of blood sample and physical function assessment at baseline.

Enrollment

32 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of colorectal cancer (any stage)
Any type of prior therapy
Age >= 18-39 years for AYA/young adult sample, age 40+ for older comparison group
For patients on active therapy: must have been diagnosed within the past three months. For survivors: must have completed curative therapy and are 6-24 months post-diagnosis
Speak English or Spanish
Ability to understand and the willingness to sign a written informed consent

Exclusion criteria

Patients who are more than 3 months from diagnosis, and survivors who are more than 24 months from initial diagnosis
Patients who have a life expectancy of less than 6 months per their medical oncologist
Patients who are deemed too ill or unable to participate by their medical oncologist (e.g., have cognitive impairment or brain metastases)
Patients who do not speak English or Spanish