Medical Expulsive Therapy Post-SWL For Renal Stones

Mansoura University

Status: Completed

Conditions: Stone, Kidney; Urolithiasis; Urologic Diseases

Treatments: Drug: Tamsulosin; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05032287

MET SWL

Details and patient eligibility

About

To evaluate the efficacy and stone free rate of placebo versus tamsulosin as medical expulsive therapy post-SWL in patients with renal stone less than 20 mm

Enrollment: 235 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Renal stone ≤ 20 mm.
• Lower calyceal stone ≤ 15 mm

Exclusion criteria

• Women with known or suspected pregnancy or breastfeeding.
• History of alpa-blockers (more than 7 days prior to study participation)
• History of ureteral stricture
• Multiple (that is more than 2) stones
• Stone in solitary kidney (either anatomically or functionally).
• Presence of urinary sepsis.
• Estimated glomerular filtration rate < 30 ml/min
• Contraindication or allergy to tamsulosin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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235 participants in 2 patient groups, including a placebo group

tamsulosin

Active Comparator group

Description:

tamsulosin 0.4 mg once daily

Treatment:

Drug: Tamsulosin

Placeb

Placebo Comparator group

Description:

Placebo once daily

Treatment:

Drug: Placebo