Medical Follow-up of New Cases of Polyarthritis in Children and Young Adults

Université Catholique de Louvain

Status: Enrolling

Conditions: Seronegative Arthritis; Diffuse Systemic Sclerosis; Psoriatic Arthritis; Systemic Lupus Erythematosus; Juvenile Idiopathic Arthritis; Rheumatoid Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT07000916

Cap 48 polyarthrite

Details and patient eligibility

About

Population:

Juvenile idiopathic arthritis (JIA), rheumatoid arthritis (RA) and seronegative / psoriatic / undifferentiated arthritis (UA), systemic lupus erythematosus (SLE) or diffuse systemic sclerosis dSS).

Naïve to basic treatment OR treated for ≤ 3 months; except for patients with JIA.

These 5 cohorts will be subject to standardized clinical monitoring.

Full description

This study is proposed by the Rheumatology and Pediatrics departments of the 3 French-speaking Universities.

The first objective will be to include a progressive number of new young patients (≤ 50 years) in order to optimize and standardize care and clinical response objectives. The number of 25% of new incident cases will be sought with an increase of 20% each year during the 5 to 10 years of this project.

Population: JIA, RA/UA, SLE, dSS (American Congres of Rheumatology criteria). Naïve to basic treatment OR treated for ≤ 3 months; except for patients with JIA.

These 5 cohorts will be subject to standardized clinical monitoring and specific objectives that will make it possible to analyze the number of patients with a good control of the disease and/or a clinical remission, defined according to the international criteria.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 2 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of juvenile idiopathic arthritis, rheumatoid arthritis and seronegative / psoriatic / undifferentiated arthritis, systemic lupus erythematosus or diffuse systemic sclerosis (ACR criteria).
• Naïve to basic treatment OR treated for ≤ 3 months; except for patients with JIA.

Exclusion criteria

• Treated for > 3 months
• > 50 years old

Trial design

1,000 participants in 5 patient groups

juvenile idiopathic arthritis (JIA)

Description:

aged \<= 16 y.o. recent diagnosis of JIA and DMARDs treatment-naive patients; aged \<18 y.o. recent diagnosis of JIA

rheumatoid arthritis (RA)

Description:

aged =\>18; =\< 50 y.o. recent diagnosis of RA and DMARDs treatment-naive patients

diffuse systemic sclerosis (dSS)

Description:

aged =\>18; =\< 50 y.o. recent diagnosis of dSS and DMARDs treatment-naive patients

seronegative arthritis (UA)

Description:

aged =\>18; =\< 50 y.o. recent diagnosis of UA and DMARDs treatment-naive patients

systemic lupus erythematosus (SLE)

Description:

aged =\>18; =\< 50 y.o. recent diagnosis of SLE and DMARDs treatment-naive patients