Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents

Mansoura University

Status: Completed

Conditions: Enamel Caries

Treatments: Drug: Casein phosphopeptide amorphous calcium phosphate; Drug: Silver diamine fluoride- potassium iodide; Drug: experimental tricalcium silicate

Study type: Interventional

Funder types: Other

Identifiers

NCT05296213

M03060819

Details and patient eligibility

About

Medical Treatment of Early-Enamel Carious Lesion using Different Remeneralizing agents

Full description

Medical management of incipient lesions by application of remineralizing agents like fluoride therapy, amorphous calcium phosphate (ACP), and Casin phosphopeptide amorphous calcium phosphate (CPP-ACP) has proved to be effective in reversing such lesions.

Fluoride was considered the "gold standard" remineralizing agent , However several recent researchers found that; the ideal remineralizing agents should diffuse or deliver calcium and phosphate ions into early enamel lesion.

Calcium-silicate based material such as β-CaSiO3 and β-Ca2SiO4 play an important role in hard tissue regeneration, showing good bioactivity and biocompatibility and can induce bone like apetite formation in stimulated body fluids. when β-CaSiO3 and β-Ca2SiO4 come in contact with saliva it will be dissolve forming silanol group (Si-O ) on the enamel surface which can bind to Ca ions and inducing the precipitation of hydroxyapatite.

In the light of this, this study was designed to compare the remineralization potential of silver diamine flouride/ potassium iodide, casin phosphopeptide amorphous calcium phosphate and experimental tricalcium silicate on early enamel lesions.

Enrollment: 45 patients

Sex: All

Ages: 15 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with early enamel lesions (ICDAS score 1 and 2).
• Patients with normal occlusion .
• Patients must have a good oral hygiene
• patients free from any systemic diseases and don't receive any medication

Exclusion criteria

• smoker patients
• pregnant females
• patients with bad oral hygiene
• patients with enamel defects ( Amelogenesis Imperfecta, fluorosis, cracks or any developmental defects)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

45 participants in 3 patient groups

silver diamine fluoride-potassium iodide SDF-KI (riva star)

Experimental group

Description:

SDF-KI was applied once as a professional application over the early enamel lesions in cervical third of the buccal surface of molar teeth.

Treatment:

Drug: Silver diamine fluoride- potassium iodide

casein phosphopeptide amorphous calcium phosphate CPP-ACP(tooth mousse)

Experimental group

Description:

CPP-ACP cream was applied twice daily according to manufacturer's instructions over the early enamel lesions in cervical third of the buccal surface of molar teeth.

Treatment:

Drug: Casein phosphopeptide amorphous calcium phosphate

Experimental tricalcium silicate

Experimental group

Description:

Experimental tricalcium silicate paste was applied twice daily over the early enamel lesions in cervical third of the buccal surface of molar teeth

Treatment:

Drug: experimental tricalcium silicate