Medication Integration in Treatment of Comorbid Adolescent Substance Users/Attention Deficit Hyperactivity Disorder (MIP)

The National Center on Addiction and Substance Abuse at Columbia University

Status and phase: Completed; Phase 1

Conditions: Attention Deficit Disorder; Attention Deficit Hyperactivity Disorder

Treatments: Behavioral: MIP Protocol

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01369459

1R21DA031305-01A1 (U.S. NIH Grant/Contract)

CASA2011MIP

Details and patient eligibility

About

The goal of this project is to develop and test a brief protocol designed to systematically integrate pharmacological interventions for Attention Deficit Hyperactivity Disorder (ADHD) into behavioral treatment services for adolescent substance users with co-morbid ADHD in everyday care. Primary study aims will yield proof-of-concept data on MIP feasibility and fidelity in usual care and evidence of MIP impact on psychiatric and behavioral services utilization, medication acceptance and compliance, and satisfaction with treatment services.

Enrollment: 14 patients

Sex: All

Ages: 13 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 13-17 years
• Caregiver able to participate in treatment
• One day of alcohol use to intoxication or illegal drug use in the past 30 days (or 30 days prior to living in a controlled environment)
• endorsement of one or more DSM-IV symptoms of Substance Use or Alcohol Dependence/Abuse
• meet ASAM criteria for outpatient substance use treatment
• meet DSM-IV criteria for ADHD (with or without onset prior to age 7)
• not enrolled in any behavioral treatment

Exclusion criteria

• MDD
• Bipolar Disorder
• Mental Retardation
• PDD
• medical or psychiatric illness requiring hospitalization
• current psychotic features
• currently suicidal

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 2 patient groups

Family Counseling with MIP Protocol

Experimental group

Description:

We intend for MIP to be a 5-session, family-based protocol delivered during the early portion of ASU treatment. MIP will contain three elements deemed essential for integrating pharmacological interventions into outpatient behavioral treatment for youth: (1) standardized psychiatric assessment and family-focused psychoeducation about the target problem; (2) an approved medication regimen with demonstrated efficacy for comorbid populations; (3) family-based interventions for medication acceptance and coordination of psychiatric and behavioral services. MIP will incorporate research-proven interventions from each of these core areas.

Treatment:

Behavioral: MIP Protocol

Historical Control

No Intervention group