Medications With or Without WeightWatchers (Meds WOW-WW)

Michelle Cardel, PhD, MS, RD

Status: Completed

Conditions: Overweight; Obesity

Treatments: Behavioral: WW Clinic

Study type: Interventional

Funder types: Industry

Identifiers

NCT06470659

Meds WOW-WW

Details and patient eligibility

About

The study compares the effectiveness of adults living with overweight or obesity taking weight management medications alone vs taking them with behavioral and lifestyle support. The primary outcome is percent body weight lost at 12-weeks.

Enrollment: 101 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI of >30 or BMI of >27 with one or more weight related medically qualifying condition (hypertension, dyslipidemia, sleep apnea, cardiovascular disease)
• Determined eligible for Bupropion/Naltrexone or Liraglutide by WW Clinic medical provider and initiated a medication management plan

Exclusion criteria

• Diabetes
• Uncontrolled hypertension
• History of seizures
• History of glaucoma
• History of chronic kidney disease
• Currently taking bupropion
• Currently taking naltrexone
• Current or previous history of anorexia or bulimia nervosa
• Engagement with vomiting or laxative use within the last 28 days with the aim of controlling their shape or weight
• Currently taking opioids
• Previous surgical obesity treatment
• Use of other anti-obesity medication in last 90 days or a GLP1 in the last 180 days
• Lost weight >11 lbs in the last 90 days
• Pregnant, breastfeeding, intends to become pregnant, of child-bearing potential and not using a highly effective contraceptive method
• Any other reason rendering a participant unsuitable for trial participation, as determined by a clinician or study investigator

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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101 participants in 2 patient groups

Meds alone

No Intervention group

Description:

Participants in this group do not receive behavioral or lifestyle support alongside their medications. The medications are not part of the intervention (it is part of the eligibility criteria).

Meds plus WW

Experimental group

Description:

Participants in this group receive behavioral or lifestyle support from WW Clinic alongside their medications. The medications are not part of the intervention (it is part of the eligibility criteria).

Treatment:

Behavioral: WW Clinic