MEDIR Medulloblastome

Grenoble Alpes University Hospital Center (CHU)

Status

Unknown

Conditions

Child Cancer Brain

Treatments

Other: IRMf Bold

Study type

Observational

Funder types

Other

Identifiers

NCT01197924

07PHN01

Details and patient eligibility

About

The medulloblastome is a tumour of the child relatively frequent usually sitting in the cerebellum and treated by surgery, radiotherapy and chemotherapy. After the treatment, these children present cognitive disorders and in particular disorders of the working memory associated with a fall with the school performances. By studying a troop of 32 children, we could show that the disorders of the working memory prevail during the handling of information presented visually and with verbal contents. However, the specific engagement of the cerebellum in the tasks of working memory according to the sensory method of presentation (visual or auditive) and the nature (verbal or not verbal) of information to treat vague remainder. Moreover, the anatomical attacks associated with these disorders remain ignored in these children. The best comprehension of the bases anatomo-functional calculuses which underlie their cognitive deficits is essential to develop new strategies of treatment and rehabilitation.

Objectives:

To describe in IRMf of the common and specific networks engaged during the execution of the tasks of working memory according to the sensory type and the nature of information to be memorized.
To describe in IRMf the cortical reorganizations necessary to the execution of the mnemic tasks among patients.
To describe in anatomical IRM and of the tensor of diffusion lesions cérébelleuses and cerebral, cortical and subcortical associated with these disorders.
To study the correlations radio-private clinics between data IRM and the data neurological and neuropsychological of the children explored according to protocol ONCORAP

Full description

The functional study should make it possible to show the specifically committed networks according to the cognitive tasks. Among patients, the relative difficulty to carry out the tasks of working memory should be accompanied by a recruitment of the dorso-side cortex préfrontal, lower and parietal frontal cortex but also of the median frontal areas such as the additional driving surface, the former cingulum. Moreover, one deterioration of the engagement of the cérébello-cerebral network (left lower parietal cortex and cérébelleux cortex lower right) facilitating the execution of these tasks should be observed.

Enrollment

80 estimated patients

Sex

All

Ages

8 to 12 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Old from 8 to 12 years
Total IQ > 70 for the participation in the study and/or age développemental 7 years minimum
Treaties for a médulloblastome after the 6 years age in remission supplements with 6 months a minimum time compared to the end of all the treatments
Followed within the framework of the protocol of evaluation of the mnemic and attentionnelles after-effects
Sensory after-effects compatible with the realization of the tasks and good performances at the time of the preceding drive the IRM
Absence of counter-indication to the IRM
Absence of catch of méthylphénidate (Ritaline®) for the treatment of disorders attentionnels 48h before the IRM
Enlightened assent signed by at least one of the two parents or holders of the parental authority and by the child (minor)

Exclusion criteria

Agitation or movements of the head at the time the IRM
Artifacts of magnetic susceptibility in projection of the areas of interest (intracranial haemorrhage, cortical and/or metal remains post-operative) • Bad execution of the cognitive tasks
Tumoral relapse in the course of protocol