Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes (MCT+AE)

Université de Sherbrooke

Status: Completed

Conditions: Prediabetic State

Treatments: Dietary Supplement: MCT; Dietary Supplement: Aerobic exercise; Dietary Supplement: MCT+ aerobic exercise; Dietary Supplement: Control day

Study type: Interventional

Funder types: Other

Identifiers

NCT02678390

2015-508

Details and patient eligibility

About

The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes. After an evaluation of the metabolism (a 4-hour visit with multiple blood samples) at the beginning of the study, all the participants are taken for one-week the MCT supplement alone follow by a one-week period of taking the MCT supplement in combination with physical exercise. At the end of each period of time, the 4-hour visit for the evaluation of the metabolism is repeated.

Enrollment: 20 patients

Sex: Female

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy women group: fasting blood glucose < 6.1 mmol/L and HbA1c < 6.0 %.
• Women with prediabetes: fasting blood glucose between 6.1 and 6.9 mmol/L and HbA1c between 6.0 and 6.4 %

Exclusion criteria

• Structured physical activity (more than 2 times per week)
• Inability to practice physical exercise
• Diabetes (fasting glucose ≥ 7.0mmol/L or HbA1c ≥ 6.5%)
• Uncontrolled dyslipidemia or hypertension
• Use of medications known to affect the metabolism of lipids and carbohydrates (steroids, beta-blockers, diuretics, insulin sensitizers, etc.)
• Severe infections or inflammations

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Healthy women

Experimental group

Description:

Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling. Interventions: 1. A control day with no MCT and no aerobic exercise. 2. A 5 day consecutive MCT intake of 30 g/day. 3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity. 4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.

Treatment:

Dietary Supplement: Control day

Dietary Supplement: MCT+ aerobic exercise

Dietary Supplement: Aerobic exercise

Dietary Supplement: MCT

Women with prediabetes

Experimental group

Description:

Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling. Interventions: 1. A control day with no MCT and no aerobic exercise. 2. A 5 day consecutive MCT intake of 30 g/day. 3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity. 4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.

Treatment:

Dietary Supplement: Control day

Dietary Supplement: MCT+ aerobic exercise

Dietary Supplement: Aerobic exercise

Dietary Supplement: MCT