Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease (MCT-MA)

Université de Sherbrooke

Status: Completed

Conditions: Alzheimer's Disease

Treatments: Dietary Supplement: 1-month of C8 MCT oil; Dietary Supplement: 1-month of 60-40 MCT oil

Study type: Interventional

Funder types: Other

Identifiers

NCT02709356

2016-547

Details and patient eligibility

About

Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.

Full description

Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.

Enrollment: 20 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Good general health for Control group
• Diagnosis of Alzheimer's disease (NINCDS-ADRDA criteria) for AD group

Exclusion criteria

• Depression
• Medical or psychiatric conditions that could interfere with study participation
• Fasting plasma glucose ≥7.0 mM (diabetes or prediabetes)
• Already on MCT supplementation
• Clinically-significant gastrointestinal disease/conditions
• Clinically-significant liver disease/dysfunction
• Clinically-significant renal disease/dysfunction
• Clinically-significant cardiac disease/conditions
• Hypertension
• Uncontrolled dyslipidaemia
• Vitamin B12 deficiency
• Structured physical activity (more than 3 times/week)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Alzheimer's disease

Experimental group

Description:

Patients with mild Alzheimer's disease. 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)

Treatment:

Dietary Supplement: 1-month of 60-40 MCT oil

Dietary Supplement: 1-month of C8 MCT oil

Controls

Experimental group

Description:

Healthy elderly people 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)

Treatment:

Dietary Supplement: 1-month of 60-40 MCT oil

Dietary Supplement: 1-month of C8 MCT oil