Medium Chain Triglycerides Plasma Profile and Their Metabolites After Oral Peptamen Intake

Nestlé

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Peptamen 1.5

Study type

Interventional

Funder types

Industry

Identifiers

NCT02241681

14.22.MET

Details and patient eligibility

About

Medium Chain Triglycerides (MCT) have been used for many years as a good source of lipid to decrease potential for fat malabsorption. However, the pharmacokinetics of MCT and of their metabolites have not been explored in details.

This is an exploratory study aiming at determining the plasma level of MCT and their metabolites after oral intake of Peptamen.

Full description

20 subjects will be given 250mL of peptamen 1.5 twice, with 4 hours of interval, on a single day.

Plasma kinetics of MCTs and their metabolites will be made over 8 hours from baseline

Enrollment

20 patients

Sex

All

Ages

20 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy males and females
Aged between 20 and 65 years old
BMI in the normal range (18.5 to 25.0 kg/m2)
Having signed his/her consent form

Exclusion criteria

Clinically relevant digestive (including malabsorption or major surgery), renal, hepatic, pancreatic or metabolic disease (diabetes, hypo or hyperthyroidism, hypo or hypercorticism), as determined by the medical (screening) visit and a standard blood chemistry analysis (glucose, total cholesterol, ALDL, AHDL, triglycerides, ASAT, ALTI, gamma GT, RCRP, creatinine)
Medically diagnosed anemia based on a blood formula
Food allergy, lactose intolerance and intolerance to milk proteins (anamnesis)
Smokers (anamnesis)
Pregnancy (anamnesis)
Under corticoids or hormone (adrenal, thyroid) treatment
Alcohol intake: > 2 units a day (anamnesis)
Consumption of illicit drugs (anamnesis)
Having given blood within the last month, or willing to make a blood donation until one month following the end of the study
Subject who cannot be expected to comply with the study procedures, including consuming the test product
Currently participating or having participated in another clinical trial during the last month prior to the beginning of this study.