Medium-term Effects of Molecular Hydrogen on Metabolic Fitness in Obesity

Center for Health, Exercise and Sport Sciences, Serbia

Status and phase: Completed; Phase 3

Conditions: Obesity

Treatments: Dietary Supplement: Molecular hydrogen; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02832219

16-AD

Details and patient eligibility

About

Molecular hydrogen (H2) effectively tackles obesity-related disorders in animal models yet no studies so far investigated the effectiveness of H2 for improving biomarkers of obesity in humans. In this double blind, placebo-controlled, crossover pilot trial, the investigators will evaluate the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in middle age overweight women, with hydrogen administered orally for 4 weeks.

Enrollment: 12 patients

Sex: Female

Ages: 55+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age > 55 years
• body mass index > 25 kg/m2

Exclusion criteria

• no history of H2 supplementation within the 4 weeks before study commenced
• no major chronic diseases, as evaluated by pre-participation health screening and clinical chemistry

Trial design

12 participants in 2 patient groups, including a placebo group

Molecular hydrogen

Experimental group

Description:

Molecular hydrogen, tablet, 2 g/day, 4 weeks

Treatment:

Dietary Supplement: Molecular hydrogen

Placebo

Placebo Comparator group

Description:

Cellulose, tablet, 2 g/day, 4 weeks

Treatment:

Dietary Supplement: Placebo