Medium-term Follow-up of Patients With Obstetric Antiphospholipid Syndrome: MRI Study of White Matter (APS Follow Up)

Centre Hospitalier Universitaire de Nīmes

Status

Completed

Conditions

Antiphospholipid Syndrome

Treatments

Procedure: Diffusion tensor imaging MRI

Study type

Interventional

Funder types

Other

Identifiers

LOCAL/2018/JCG-01

Details and patient eligibility

About

The investigators hypothesize that the white matter of patients with obstetric antiphospholipid syndrome deteriorates over time

Enrollment

40 patients

Sex

Female

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

The patient must have given their free and informed consent and signed the consent form
The patient must be a member or beneficiary of a health insurance plan
The patient is at least 18 years old
For the target population: only women included in the publication by Pereira et al (2016) will be included, with no obsteric history (fetal death >10 weeks or 3 unexplained consecutive losses <10 weeks)
For the test group: Patients must be positive for antiphospholipid antibodies based on results from Pereira et al (2016)
For the control group. Patients must be negative for antiphospholipid antibodies according to results from Pereira et al (2016)

Exclusion criteria

The subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study
The subject refuses to sign the consent
It is impossible to give the subject informed information
The patient is under safeguard of justice or state guardianship
The patient is pregnant, parturient or breast feeding
The patient is claustrophobic
The patient has a metallic foreign body (e.g. pacemaker)
The patient has experienced pregnancy loss linked to infectious, metabolic, anatomic or hormonal factors