Melanocortin 4 Receptor Mutations and Obesity-associated Diseases (Mc4Obes)

University of Copenhagen

Status: Completed

Conditions: Obesity

Treatments: Other: No intervention

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01849705

H-2-1012-108 (Registry Identifier)

B-298

Details and patient eligibility

About

Mutations in the melanocortin 4 receptor (MC4R) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity.

Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity.

The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.

Enrollment: 226 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-70 years
• Men and women
• BMI > 30 kg/m^2

Exclusion criteria

• Uncontrolled type 2 diabetes
• Bariatric surgery
• Use of anti-obesity medication

Trial design

226 participants in 1 patient group

All subjects

Description:

No intervention

Treatment:

Other: No intervention