Melatonin and Adiponectin in Hypertensive Kidney Transplant

Sheba Medical Center

Status: Completed

Conditions: Hypertension; Kidney Transplant

Study type: Observational

Funder types: Other

Identifiers

NCT00498576

SHEBA-07-4730-AL-CTIL

Details and patient eligibility

About

Recently we have shown that melatonin secretion is impaired in rats with metabolic syndrome. We have also demonstrated that exogenic melatonin supplementation can improve blood pressure profile in nondipper patients.

The aim of this study is to find whether there is a difference between melatonin secretion in hypertensive kidney recipients versus "normal" hypertensive patients. Secondly, to ask if there is any correlation between melatonin secretion and adiponectin levels.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• hypertension
• kidney transplantation ( group 1)
• good renal function

Exclusion criteria

• diabetes mellitus
• cancer
• renal failure

Trial design

60 participants in 3 patient groups

1

Description:

kidney transplant with hypertension

2

Description:

hypertensive patients with native kidneys

3

Description:

healthy controls