Melatonin and Coronary Artery Calcification

Chinese PLA General Hospital (301 Hospital)

Status

Completed

Conditions

Coronary Artery Calcification

Study type

Observational

Funder types

Other

Identifiers

NCT03967366

MelandCAC

Details and patient eligibility

About

The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.

Full description

Coronary artery calcification (CAC) is prevalent in coronary artery disease (CHD), and the extent of CAC predicts cardiovascular risk. The causes of CAC include dysregulated matrix metabolism, epitaxial mineral deposition, inflammation, oxidative stress, and apoptosis. Melatonin is the main indoleamine produced by the pineal gland; it is known recently to have anti-inflammatory, anti-cancer and antioxidant activities. Several studies have shown that melatonin protects against inflammation and apoptosis in vascular calcification. Melatonin also inhibits oxidative stress-induced apoptosis and calcification in endplate chondrocytes. However, no study has evaluated whether melatonin is associated with CAC in patients with coronary atherosclerosis. The investigators planned to research the association between plasma melatonin and coronary artery calcification.

Enrollment

574 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with angina-like chest pain, were included in this study. All subjects had blood samples collected and all underwent a coronary CTA scan.

Exclusion criteria

melatonin treatment
coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery)
heart failure or cardiomyopathies
hepatic failure
renal dysfunction
haemolytic disorders
thyroid disease
neoplastic diseases
acute infectious or inflammatory conditions.