Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation

Hams Hamed Abdelrahman

Status: Completed

Conditions: Edentulous; Alveolar Process, Atrophy

Treatments: Other: Melatonin and hyaluronic acid and sinus membrane elevation; Procedure: sinus membrane elevation without any materials

Study type: Interventional

Funder types: Other

Identifiers

NCT04625179

Maxillary sinus augmentation

Details and patient eligibility

About

melatonin proved an ability to repair bone defects and enhance osseointegration of dental implants. Also, hyaluronic acid has osteopromoting properties.

the effect of melatonin and hyaluronic acid on the newly formed bone in maxillary sinus augmentation was evaluated

Full description

16 participants with missing maxillary posterior teeth and residual alveolar ridge of at least 5 mm will be equally and randomly divided into two groups.

The study group will receive melatonin and hyaluronic acid after sinus membrane elevation and simultaneous implant placement while the control group will not receive any materials after sinus membrane elevation and simultaneous implant placement.

Enrollment: 16 patients

Sex: All

Ages: 30 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age range will be between (30 - 50) years old.
• Patients with missed one or more of posterior teeth with minimum residual bone height 5 mm
• Adequate inter-occlusal space of at least 8 mm

Exclusion criteria

• Maxillary sinus diseases.
• Previous sinus surgery like the Caldwell-Luc operation.
• History of chemotherapy or radiotherapy to maxilla.
• Presence of Underwood's septa/severe sinus floor convolutions.
• Systemic disease affecting bone metabolism.
• Uncontrolled diabetes mellitus.
• Heavy smokers.
• Para functional habits.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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16 participants in 2 patient groups

Melatonin and hyaluronic acid and sinus membrane elevation

Experimental group

Description:

melatonin and hyaluronic acid will be placed after maxillary sinus membrane elevation and simultaneous dental implants placement

Treatment:

Other: Melatonin and hyaluronic acid and sinus membrane elevation

sinus membrane elevation without any materials

Active Comparator group

Description:

no materials will be placed after maxillary sinus membrane elevation and simultaneous dental implants.

Treatment:

Procedure: sinus membrane elevation without any materials