MELT - MRI Evaluation of Lymphoma Treatment

University College London (UCL)

Status: Completed

Conditions: Lymphoma, Hodgkin

Study type: Observational

Funder types: Other

Identifiers

NCT01459224

UCL10/0271

CRUK ASC 12707 (Other Grant/Funding Number)

Details and patient eligibility

About

Patients who are newly diagnosed with Hodgkin's lymphoma will undergo disease staging at diagnosis and initial treatment response assessment. At each time point (initial staging and treatment response assessment) in addition to standard imaging investigations (PET CT, Chest CT, anatomical MRI of the abdomen and pelvis and abdominal USS), patients will undergo an extended MRI scan.

Full description

The trial will be a single centre cohort study in patients newly diagnosed with Hodgkin's lymphoma undergoing disease staging at diagnosis and initial treatment response assessment. At each time point (initial staging and treatment response assessment) in addition to standard imaging investigations (PET CT, Chest CT, anatomical MRI of the abdomen and pelvis and abdominal USS), patients will undergo advanced anatomical and functional MRI sequences.

Enrollment: 58 patients

Sex: All

Ages: 5 to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 5 to 20 years (inclusive) with participant and parent/guardian informed consent
• Histologically confirmed first presentation of Hodgkin's Lymphoma
• Either entered into the Euronet PHL-C1 trial or LP1 trials OR not formally entered into the Euronet trials but treated on the chemotherapy regimens of the Euronet trials for classical and lymphocyte predominant Hodgkin Lymphoma

Exclusion criteria

• Contraindications to MRI (e.g. pacemaker)
• Previous malignancy or previous chemotherapy or radiotherapy treatment for malignancy
• Pregnancy or nursing