Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia

University of California San Diego logo

University of California San Diego

Status and phase

Completed
Phase 4

Conditions

Healthy
Schizophrenia
Schizo Affective Disorder
Schizoaffective Disorder

Treatments

Drug: Memantine
Drug: Placebos

Study type

Interventional

Funder types

Other

Identifiers

NCT03860597
R01MH094320

Details and patient eligibility

About

This application seeks to determine if neurophysiological metrics of memantine (MEM)-enhanced early auditory information processing (EAIP) in schizophrenia (SZ) mediate gains in auditory processing fidelity (APF) and auditory learning.

Enrollment

42 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • diagnosis of schizophrenia OR schizoaffective-depressed OR healthy subjects
  • ages 18-50 for all subjects
  • double barrier contraception for all subjects
  • not pregnant for all subjects

Exclusion criteria

  • DSM-IV Axis I or II Diagnosis for for healthy subjects
  • MEM or amantadine for patients
  • current substance abuse for all subjects
  • current recreational drug use for all subjects
  • history of other significant medical illness (e.g. cancer, diabetes, heart disease, HIV, seizures) for all subjects
  • open head injury or closed head injury with loss of consciousness > 1 min for all subjects
  • hearing or visual impairment for all subjects
  • pregnancy for all subjects
  • dementia for all subjects
  • mental retardation for all subjects

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

42 participants in 2 patient groups, including a placebo group

Memantine
Active Comparator group
Treatment:
Drug: Memantine
Placebo
Placebo Comparator group
Treatment:
Drug: Placebos

Trial documents
2

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems