Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance

University Hospital, Strasbourg, France

Status: Unknown

Conditions: Severe Sepsis and Septic Shock

Study type: Observational

Funder types: Other

Identifiers

NCT02391792

DC2012-1633

Details and patient eligibility

About

Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with merging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This a prospective observational study of circulating MPs and blood coagulation in septic shock patients admitted in medical intensive care units (ICUs) of four tertiary hospitals at baseline (D1, D2, D3, D4, D7).

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Septic shock (patients)
• Without septic shock (control)
• Informed consent

Exclusion criteria

• Class IV heart failure
• Child-plugh grade C cirrhosis
• Cancer under active treatment
• BMI>35kg/m2
• Moribund patient
• DNR decision

Trial design

300 participants in 3 patient groups

patients

Description:

patients with septic shock

control

Description:

patients without septic shock

healthy volunteers