Memory Deterioration in Alzheimer Disease (MemAD)

Norwegian University of Science and Technology

Status: Enrolling

Conditions: Alzheimer Disease; Neurodegenerative Diseases; Memory Impairment; Magnetic Resonance Imaging

Treatments: Diagnostic Test: Neuropsychologic test (MoCA); Biological: Stool samples; Biological: Blood samples; Device: EEG; Device: 7T MRI

Study type: Observational

Funder types: Other

Identifiers

NCT07118137

490656

Details and patient eligibility

About

Semantic AD

Enrollment: 30 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Confirmed diagnosis based on current ICD criteria for AD or MCI .
• >55years.
• Norwegian native speaker
• Lives at home and not in a health institution

Exclusion criteria

• Patients with severe cognitive impairment that prevents assessment with the selected modalities (planned cut-off: CDR > 2).

• Presence of brain tumors.

• History of traumatic brain injury.

• History of cranial surgery.

• Contraindications to the selected imaging modalities (e.g., 7T MRI or EEG).

• Diagnosis of other neurodegenerative diseases such as Parkinson's disease or ALS.

  7T MRI contraindications:

• Large tattoos close to the head region, permanent makeup or unremoveable piercings

• Certain models of pacemakers (if pacemaker implantet, MRI physicist at 7T-lab will be conferred)

• Implantet metal in body (clips, stents, prothesis, skrews, plates, teeth etc.)

Trial design

30 participants in 2 patient groups

Mild Alzheimer

Description:

Patients above 65 diagnosed with Alzheimer's Disease according to appropriate ICD-criterias.

Treatment:

Device: EEG

Device: 7T MRI

Biological: Blood samples

Biological: Stool samples

Diagnostic Test: Neuropsychologic test (MoCA)

Controls

Description:

Age- and gender-matched control group.

Treatment:

Device: EEG

Device: 7T MRI

Biological: Blood samples

Biological: Stool samples

Diagnostic Test: Neuropsychologic test (MoCA)