Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects (I-TSPT-R)

Centre Hospitalier de Niort

Status

Completed

Conditions

Post-Traumatic Stress Disorder in Old Age

Treatments

Other: Post Traumatic Stress Disorder

Study type

Interventional

Funder types

Other

Identifiers

NCT03897855

CH-NIORT-2018-02

Details and patient eligibility

About

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.

This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.

The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

Enrollment

20 patients

Sex

All

Ages

65 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Regarding the constitution of the group patient (TSPT-R):

Subjects 65 years of age or older
Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
The traumatic event must have taken place at the latest before 65 years
Affiliated person or beneficiary of a social security scheme.
Written consent before any examination required by research)

Regarding the constitution of the control group:

Subjects 65 years of age or older
No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
Affiliated person or beneficiary of a social security scheme.
Written consent before any examination required by the research).

Exclusion criteria

For both groups:
Acute or chronic cognitive impairment known
GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:
- 22 if no diploma
- 23 if certificate of study
- 25 if patent
- 26 if bin or more
- Remove one point at each threshold if age> 80 years
Sensory or motor disorder preventing the passing of different tests
Psychotic disorder
Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)
Disorder of the use of a moderate or severe substance (except tobacco).
Patients under guardianship or curatorship.