Memory Study of Youngest Women Enrolled in the Women's Health Initiative Hormone Therapy (HT) Arm (WHIMS-Y)

Wake Forest University (WFU)

Status: Completed

Conditions: Dementia

Study type: Observational

Funder types: Other

Identifiers

NCT01124773

699

Details and patient eligibility

About

WHIMS-Y provides valuable information on the long-term effects on risk of cognitive impairment of hormone therapy in a subset of WHI participants in the WHI Hormone Trials. Following cessation of study-prescribed HT cognitive function and impairment were assessed.

Full description

The Women's Health Initiative Memory Study of Younger Women (WHIMS-Y) is proposed to assess the long-term impact of random assignment to postmenopausal hormone therapy (equine estrogen alone or in combination with medroxyprogesterone versus placebo) among women who were aged 50-54 at the time of randomization into the WHI hormone trials. Secondary objectives relate to the consistency of any treatment effects across unopposed or opposed therapy and whether there exists evidence of graded relationships between cognitive effects and age of administration, years from menopause, and baseline risk factors for cognitive impairment.

Enrollment: 1,362 patients

Sex: Female

Ages: 50 to 54 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Must be enrolled in the Women's Health Initiative Extension

Exclusion criteria

• Not enrolled in the Women's Health Initiative Extension

Trial design

1,362 participants in 1 patient group

Previous HT use and cognition

Description:

Women who were aged 50-54 at the time of randomization into the WHI hormone trials.