Memory Support System for Older Chinese Americans With Mild Cognitive Impairment

Mount Sinai Health System

Status: Enrolling

Conditions: Mild Cognitive Impairment (MCI)

Treatments: Behavioral: Brain Health Education; Behavioral: Memory Support System

Study type: Interventional

Funder types: Other

Identifiers

NCT07142499

GCO 22-1738

Details and patient eligibility

About

The Memory Support System (MSS) from the Healthy Action to Benefit Independence & Thinking® (HABIT) Program is an evidence-based, non-pharmacological intervention for mild cognitive impairment (MCI). Despite the clinical benefits and feasibility, the MSS was primarily developed and used with non-Hispanic White, English-speaking adults. Racial/ethnic minority groups are chronically under-enrolled in clinical trials for Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) due to lack of linguistically and culturally appropriate adaptation of assessment measures and intervention protocols. The purpose of this research study is to examine whether the MSS from HABIT can help Chinese American older adults with mild thinking and memory problems. Target recruitment is 60 Chinese American adults who are primarily Mandarin- (n=30) and Cantonese-speaking (n=30). Forty participants will participate in the trainer-led day planner training and 20 will participate in self-study of the day planner and receive brain health education. Each participant will also be asked to identify a study partner to participate with them.

Enrollment: 7 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria:

• self-identify as Chinese American;
• age 55 and above;
• a diagnosis of MCI as confirmed through documented clinical assessment and/or research-based diagnostic criteria;
• predominantly Cantonese- or Mandarin-speaking;
• able to read and write in Chinese;
• visual and auditory acuity adequate for cognitive testing;
• willing to complete the assessment measures;
• having someone in regular contact to serve as a study partner/informant;
• absence or stable use of prescribed memory-enhancing medications within the last 3 months.

Exclusion criteria include:

• any significant neurologic disease that would impact their participation and completion of the trial;
• history of psychiatry disorder (DSM 5 criteria) within the last 12 months;
• history of reading or writing disability sufficient to interfere with MSS training; or
• concurrent participation in another relevant clinical trial.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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7 participants in 2 patient groups

MSS Intervention Group

Experimental group

Description:

10-session MSS Training Workbook. Additional sessions beyond the standard 10 sessions can be added up to a maximum of 15 total sessions.

Treatment:

Behavioral: Memory Support System

Brain Health Education Control Group

Active Comparator group

Description:

10 session Brain Health Education. Additional sessions beyond the standard 10 sessions can be added up to a maximum of 15 total sessions.

Treatment:

Behavioral: Brain Health Education