Memory Training and Neural Plasticity (WMTrain)

University of Michigan

Status: Terminated

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Working Memory Training

Study type: Interventional

Funder types: Other

Identifiers

NCT05380739

HUM00199574

Details and patient eligibility

About

This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).

Full description

Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).

Enrollment: 24 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• MCI Diagnosis
• Right-handedness
• MRI-eligibility for MRI participants

Exclusion criteria

• History of other contributing neurological or medical conditions known to affect cognitive functioning
• Significant mental illness
• Sensory impairments that limit ability to participate
• History of alcohol or drug abuse/dependence

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 3 patient groups

In-Person, MCI

Active Comparator group

Description:

Participants diagnosed with MCI will undergo 10 sessions of WM training in person.

Treatment:

Behavioral: Working Memory Training

Online, MCI

Active Comparator group

Description:

Participants diagnosed with MCI will undergo 10 sessions of WM training online.

Treatment:

Behavioral: Working Memory Training

Online, Healthy

Active Comparator group

Description:

Cognitively intact older adults will undergo 10 sessions of WM training online.

Treatment:

Behavioral: Working Memory Training