Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment

University of California, Los Angeles (UCLA)

Status: Completed

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Memory Training; Behavioral: Kundalini yoga and meditation

Study type: Interventional

Funder types: Other

Identifiers

NCT01983930

13-000821

Details and patient eligibility

About

The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints when compared to weekly classes of memory training with daily homework assignments.

Full description

The purpose of this pilot study intervention is to investigate brain mechanisms of response to memory enhancement training (MET) compared to Kundalini yoga and "Kirtan Kriya" meditation using functional magnetic resonance imaging (fMRI) that will be acquired from each subject at baseline and at 12 weeks (post-randomization).

Overall, the investigators anticipate recruiting 66 adults with memory complaints and diagnosed with MCI for adults 55 years old and older. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and "Kirtan Kriya" meditation class for 60 minutes per week. All assessments will be completed immediately after the interventions for a total of 10 visits in 12 weeks and a follow-up visit at 6 months (24 weeks)to monitor the overall benefit of the intervention.

Enrollment: 81 patients

Sex: All

Ages: 55 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mild cognitive impairment amnestic type
• Clinical Dementia Rating scale score of 0.5
• SufficientEnglish proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV
• Capacity to provide informed consent.

Exclusion criteria

• Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
• Any disabilities preventing their participation in the memory enhancement training (MET) (e.g. severe visual or hearing impairment)
• Insufficient English proficiency
• Diagnosis of dementia
• Mini Mental Health Examination score of 24 and below
• Psychoactive medications
• Participation in a psychotherapy that involves cognitive training
• Do not meet criteria for Mild cognitive impairment subtype
• Prior or current training in yoga.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

81 participants in 2 patient groups

Memory Training

Active Comparator group

Description:

Group memory training will be administered for amnestic mild cognitive impairment (MCI)

Treatment:

Behavioral: Memory Training

Kundalini yoga and meditation

Experimental group

Description:

Participants will engage in weekly yoga classes and daily 20 minute meditation

Treatment:

Behavioral: Kundalini yoga and meditation