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In this study the investigators will analyze the vaginal microbiome of menopausal women in order to shed light on its potential implication on menopausal symptoms and quality of life. Moreover, the investigators will assess the effect of hormone replacement treatment on symptoms and overall quality of life during menopause and whether women under hormone replacement treatment have distinct vaginal microbiome profiles.
Enrollment
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Inclusion criteria
Women who are females from birth
Women between 40-70 years old
Women that are US residents, understand, and speak English
Women of all race and ethnicities
Women that are postmenopausal (at least 12 consecutive months without a period)
Women with a naturally occuring menopause
Women willing to abstain from all sexual activity, feminine hygiene products (eg. douches, wipes, washes, sprays, powders, moisturizers/lubricants, deodorant suppositories, tablet suppositories, anti-itch creams, hot tubs) on the vaginal area, and any vaginal suppositories for 48 hours before sampling
Women who are healthy (without GSM)
Women who have GSM:
Women who either take or do not take HRT, including estrogen-only medicines, combination of estrogen/progestin medicines, combination of estrogen/other medicines.
Exclusion criteria
432 participants in 4 patient groups
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Central trial contact
Malcolm Bohm; Eleni Rizou, PhD
Data sourced from clinicaltrials.gov
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