Menopause Age and Anxiety-Depression

Ankara City Hospital

Status: Completed

Conditions: Menopause; Depression; Anxiety; Primary Ovarian Insufficiency (Poi); Menopausal Depression

Treatments: Other: State-Trait Anxiety Scale (STAI) 1-2; Other: Beck Anxıety Inventory (BAI)

Study type: Observational

Funder types: Other

Identifiers

NCT07295093

TABED 1-25-1981

Details and patient eligibility

About

Menopause is defined as the permanent cessation of menstrual cycles due to ovarian follicle depletion, typically occurring after age 50, and is associated with decreased estrogen levels. Primary ovarian insufficiency (POI) involves early ovarian dysfunction before age 40, with infertility as a key concern. Both menopause and POI may contribute to psychological symptoms, including anxiety and depression, influenced by sociodemographic and health factors. While literature reports anxiety in middle-aged women, data on its association with menopausal timing are limited. This study aims to compare women with POI and those undergoing natural menopause after age 40, assessing the relationship between age at menopause, anxiety, and depression, as well as the impact of fertility expectations on psychological well-being in POI patients.

Enrollment: 136 patients

Sex: Female

Ages: 24+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy women over 24 years of age who visited our hospital for routine outpatient check-ups, had been diagnosed with menopause, and had no history of psychiatric disorders before menopause.

Exclusion criteria

• Cardiovascular diseases including hypertension
• Type 1 or type 2 diabetes mellitus
• Morbid obesity
• Primary adrenal insufficiency
• Uterine fibroids
• Thyroid dysfunctions including Hashimoto thyroiditis and Grave's disease
• Hepatic dysfunctions
• Renal insufficiency
• Genetic disorders in chromosome constitution or karyotype analysis including monosomy X, trisomy X and gene mutations as BMP15, FMR I, POFIB, and GDF9
• Neurologic diseases
• Psychiatric disorders
• Autoimmune diseases or syndromes including Addison's disease, autoimmune syndromes, scleroderma, Sjogren's syndrome, myasthenia gravis, inflammatory bowel diseases, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and familial Mediterranean fever
• History of any malignancy
• History of exposure to chemotherapeutic agents or radiotherapy
• Individuals with a history of chronic or regular medication use that could cause anxiety or depression symptoms
• Individuals with a personal history of psychiatric disorders
• Individuals with a history of depression in the past 6 months.

Trial design

136 participants in 2 patient groups

Menopause group

Description:

Patients over 40 years of age who have undergone menopause and who visited our hospital's obstetrics and gynecology outpatient clinic for routine check-ups, without any additional diseases or complaints.

Treatment:

Other: Beck Anxıety Inventory (BAI)

Other: State-Trait Anxiety Scale (STAI) 1-2

Primary ovarian insufficiency (POI) group

Description:

Patients who experienced menopause before the age of 40 and who visited our hospital's obstetrics and gynecology outpatient clinic for routine check-ups, without any additional diseases or complaints.

Treatment:

Other: Beck Anxıety Inventory (BAI)

Other: State-Trait Anxiety Scale (STAI) 1-2