Mental Activity During (TMS) Therapy for Depression

Augusta University

Status: Completed

Conditions: Cognitive Impairment

Treatments: Behavioral: TMS and Lumosity®cognitive retraining; Behavioral: TMS and non cognitive computer games

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03701932

663245

Details and patient eligibility

About

The purpose of the study is to assess the effects of different types of mental activity performed while receiving transcranial magnetic stimulation (TMS) for the treatment of major depressive disorder. Our primary aim for this study is to assess the feasibility of combining TMS and computer based cognitive exercise in patients with major depressive disorder who may also have some degree of cognitive dysfunction, and to formally measure changes in mood and cognition over the course of the study.

Full description

Patients will receive TMS treatment daily for 6 weeks as part of their standard care. They will complete clinical assessments and participate in cognitive retraining through completion of 15 hours of Lumosity gaming cognitive exercises while simultaneously receiving active TMS stimulation. Those participants in the control group will complete 15 hours of computer gaming activity during the administration of active stimulation. Computer games in the control group exercises are elected by the patient from a library of intellectually and motivationally engaging games drawn from several gaming software compilations that includes Play 101 Games and Hoyle Puzzle and Board Games.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Subject has a diagnosis of depression

  • Subject has been approved and scheduled to receive TMS at Augusta University
  • Subject does not have a major neurocognitive impairment or an alcohol or substance abuse disorder, and can see images on a computer monitor.

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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11 participants in 2 patient groups

TMS and Lumosity® cognitive retraining

Experimental group

Description:

Group will receive TMS and will concurrently engage in cognitive retraining exercises comprised of the Lumosity® battery.

Treatment:

Behavioral: TMS and Lumosity®cognitive retraining

TMS and non cognitive computer games

Active Comparator group

Description:

Group will receive TMS while concurrently engaging in selected computer games from several gaming software that includes Play 101 Games and Hoyle Puzzle and Board Games®. They will also be allowed to spend time on gaming activities of their choice in order to keep them engaged

Treatment:

Behavioral: TMS and non cognitive computer games