MEP and Neuromuscular Blocker

Yonsei University Health System (YUHS)

Status: Completed

Conditions: Brain Tumor

Treatments: Drug: Arm I (MEP)

Study type: Interventional

Funder types: Other

Identifiers

NCT04768400

3-2020-0511

Details and patient eligibility

About

It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.

Enrollment: 100 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential

Exclusion criteria

1. Central or peripheral neuromuscular disease
2. Sensory or motor nerve disorder
3. Allergy to propofol, remifentanil, and rocuronium
4. Patients with pacemaker

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

rocuronium

Experimental group

Description:

Neuromuscular blockade will be performed using rocuronium.

Treatment:

Drug: Arm I (MEP)