Meperidine as the Single Sedative Agent During Esophagogastroduodenoscopy

Dalin Tzu Chi General Hospital

Status: Completed

Conditions: Esophagogastroduodenoscopy

Treatments: Drug: Meperidine; Drug: normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01547520

DalinTCGH-hsieh-02

Details and patient eligibility

About

Upper endoscopy is uncomfortable for most patients. Meperidine has both sedative and analgesic effects, so its use may be helpful for patients receiving upper endoscopy.

Full description

Unsedated esophagogastroduodenoscopy (EGD) is a useful tool for upper gastrointestinal tract examination and therapy, but it is uncomfortable for many patients. Meperidine has been widely used in colonoscopic examination for many years; however, its use in EGD has not been completely evaluated.

Enrollment: 140 patients

Sex

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing diagnostic upper endoscopy in our endoscopic room were enrolled.

Exclusion criteria

• A therapeutic upper endoscopic procedure, sedated endoscopy, contraindication to Buscopan (hyoscine N-butylbromide)
• Allergy to meperidine
• American Society of Anesthesiology (ASA) risk Class 3 or higher
• Renal failure
• Decompensated cirrhosis
• Aged less than 20 years or more than 65 years
• Pregnancy
• Refusal to provide written informed consent.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

140 participants in 2 patient groups, including a placebo group

meperidine

Experimental group

Description:

25 mg of meperidine is injected intramuscularly before EGD

Treatment:

Drug: Meperidine

placebo

Placebo Comparator group

Description:

placebo was given intramuscularly before EGD

Treatment:

Drug: normal saline