ClinicalTrials.Veeva

Menu

Meperidine for Patients Expected to Have Poor Tolerance During Diagnostic Esophagogastroduodenoscopy.

D

Dalin Tzu Chi General Hospital

Status

Completed

Conditions

Patients Undergoing Diagnostic EGD

Treatments

Drug: placebo
Drug: Meperidine

Study type

Interventional

Funder types

Other

Identifiers

NCT01948921
DalinTCGH-hsieh-2013-3

Details and patient eligibility

About

Our pilot results showed that meperidine reduce patient discomfort during EGD (esophagogastroduodenoscopy). But many patients can tolerate EGD well without any sedative agents. So the investigators target the use of meperidine on patients expected to have poor tolerance in this study, which includ young females with high anxiety level and patients with prior poor tolerance. The investigators test the hypothesis that meperidine improves tolerance and alleviates discomfort for patients expected to have poor tolerance during diagnostic EGD.

Enrollment

110 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • female youger than 65 years with high anxiety level
  • patients with previous poor tolerance of EGD

Exclusion criteria

  • a therapeutic EGD
  • sedation with other agents
  • contraindication to Buscopan (hyoscine N-butylbromide) or meperidine
  • American Society of Anesthesiology (ASA) risk Class 3 or higher, renal failure
  • age less than 20 years or more than 80 years
  • pregnancy
  • refusal to provide written informed consent. All participants signed written informed consents

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

110 participants in 2 patient groups, including a placebo group

placebo
Placebo Comparator group
Description:
1 ml normal saline will be given 5 minutes before EGD
Treatment:
Drug: placebo
meperidine
Active Comparator group
Description:
25 mg intramuscular meperidine will be given 5 minutes before EGD
Treatment:
Drug: Meperidine

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems