Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae

Ain Shams University

Status and phase: Unknown; Phase 2

Conditions: Effect of Meperidine or Drotaverine on Effacement and Dilatation of the Cervix During Labor in Full Term Primigravidae

Treatments: Drug: Drotaverine; Drug: Meperidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01236651

dr hegab protocol

Details and patient eligibility

About

Comparison Between Meperidine and Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae

Full description

Comparison Between Meperidine and Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae

Protocol of Thesis Submitted for partial fulfillment of master degree in Obstetrics & Gynecology

The aim of this work is to compare and to evaluate the efficacy of drotaverine hydrochloride versus meperidine hydrochloride on the duration of the 1st stage of labor.

Enrollment: 200 estimated patients

Sex: Male

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: ● primigravida.

• Singleton pregnancy.
• Term gestation i.e, 38-41 weeks.
• Sure, reliable dates documented by ultrasound in the 1st half of pregnancy.
• Vertex presentation with occipito anterior position.
• Efficient uterine contractions at a rate of at least 3 to 4 contractions every 10 minutes, each contraction lasting for at least 40 seconds.

Exclusion Criteria: ● Abnormal presentation or occipito posterior position.

• Multiple pregnancies.
• Cephalo-pelvic disproportion.
• Cervical surgery in the past or history of cervical injury.
• Patients on antihypertensive therapy.
• Known hypersensitivity to drotaverine or meperidine.
• If any other spasmolytic agent had been used within 48 hours.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups

meperidine and duration of 1st stage of labor

Experimental group

Description:

meperidine 100mg i.v in 1st stage of labor and calculate the duration of the 1st stage of labor

Treatment:

Drug: Meperidine

drotaverine and duration of 1st stage of labor

Experimental group

Description:

drotaverine 40mg i.v in 1st stage of labor and calculate the duration of the 1st stage of labor

Treatment:

Drug: Drotaverine