Mesenchymal Stem Cells in Central Nervous System injury2017

900 Hospital of the People's Liberation Army Joint Logistic Support Force

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Central Nervous System Injury

Treatments: Drug: UCMSCC; Drug: conventional treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT03291366

MSC-CNS2017

Details and patient eligibility

About

Central nervous system (CNS) injury leads to morbidity in patients, which has few good rehabilitation measures. Mesenchymal stem cells seem to have regenerative and tissue-repairing capabilities. The investigators design this study to infuse mesenchymal stem cells (MSCs) intrathecally to CNS injury patients, and observe the safety and efficacy by recording the change of nervous system scores, trying to prove the effect of MSC in rehabilitate CNS injury.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CNS injury > 3 months
• age > 18 years
• willing to give consent
• stable vital signs
• absence of active infectcion

Exclusion criteria

• any contradiction to intrathecal infusion
• age < 18 years
• CNS injury < 3 months
• CNS injury > 3 years

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

MSC

Experimental group

Description:

infusion of aUCMSC and conventional therapy

Treatment:

Drug: conventional treatment

Drug: UCMSCC

conventional

Active Comparator group

Description:

conventional therapy

Treatment:

Drug: conventional treatment