Mesenteric Infiltration in Ovarian Cancer (MIO)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Ovary Cancer

Treatments: Diagnostic Test: Computed Tomography

Study type: Observational

Funder types: Other

Identifiers

NCT06331130

6363

Details and patient eligibility

About

To evaluate if CT features at diagnosis in patients with HGSOC can be used to build an Artificial Intelligence model capable of discerning the pathological involvement of the mesentery, assessing the potential impediments for an optimal debulking surgery and predicting the development of resistance to platinum based chemotherapeutic agents.

Enrollment: 510 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Women with confirmed HGSOC wiht mesenteric involvment
2. Age > 18 years
3. FIGO STAGE IIIB-IV
4. Primary diagnosis
5. Signed informed consent

Exclusion criteria

1. Non-serous high grade epithelial ovarian cancer (serous low grade, mucinous, clear cell carcinoma, endometrioid or non-epithelial ovarian cancer)
2. Early stage disease (I and II stage)
3. CT scan not available
4. Non-primary diagnosis or patient subjected to neoadjuvant chemotherapy

Trial design

510 participants in 2 patient groups

Retrospective cohort

Description:

Patients affected by High Grade Seruous Ovarian Cancer with mesenteric infiltration confirmed by diagnostic laparoscopy, from January 2021 to December 2023

Treatment:

Diagnostic Test: Computed Tomography

Prospective cohort

Description:

Patients affected by High Grade Seruous Ovarian Cancer with mesenteric infiltration confirmed by diagnostic laparoscopy

Treatment:

Diagnostic Test: Computed Tomography