Metabolic and Cognitive Parameters Following Partial Sleep Deprivation

Uppsala University

Status: Unknown

Conditions: Sleep Deprivation; Sleep

Treatments: Behavioral: Working memory function task; Behavioral: Portion Size Task; Procedure: Blood sample; Behavioral: Memory tasks; Behavioral: Intake task; Procedure: Interference task

Study type: Interventional

Funder types: Other

Identifiers

NCT01823263

SleepPartialJCCB2013

Details and patient eligibility

About

The purpose of this study is to determine whether partial sleep deprivation, as compared with normal sleep, influences certain metabolic and cognitive parameters, related to food intake, hunger and memory functions, when participants are shielded from external time cues.

Full description

It is predicted that partial sleep deprivation negatively affects the hormonal status, e.g. upregulating ghrelin and other hunger-promoting hunger hormones, while showing impaired memory functions. It is also predicted that participants will tend to increase their desired portion sizes after partial sleep deprivation, compared with after a normal night's sleep.

Enrollment: 20 estimated patients

Sex: Male

Ages: 20 to 28 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Age 20-28y
• Healthy (self-reported) and not on medication
• Non-smoking
• Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported and verified by sleep diaries)
• Normal dietary habits (regular meal pattern with daily breakfast)

Exclusion criteria

• Major illness
• Taking any serious medications
• Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
• Any dietary issues with the food items provided
• A history of endocrine, neurological or psychiatric disorders
• Shift work in the previous 3 months
• Travel over several time zones within the previous two months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Partial sleep deprivation

Experimental group

Description:

Partial sleep deprivation: participants will have a 4-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed by repeated blood sampling and an 'Intake task'.

Treatment:

Behavioral: Memory tasks

Procedure: Interference task

Procedure: Blood sample

Behavioral: Intake task

Behavioral: Working memory function task

Behavioral: Portion Size Task

Normal sleep

Experimental group

Description:

Normal sleep: participants will have an 8-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed with repeated blood sampling and an 'Intake task'.

Treatment:

Behavioral: Memory tasks

Procedure: Interference task

Procedure: Blood sample

Behavioral: Intake task

Behavioral: Working memory function task

Behavioral: Portion Size Task