Metabolic and Functional Impact of Various Breakfast Models

San Donato Group (GSD)

Status: Completed

Conditions: Metabolism and Nutrition Disorder

Treatments: Other: exercise; Dietary Supplement: Breakfast

Study type: Interventional

Funder types: Other

Identifiers

NCT03240757

Colazioni/1

Details and patient eligibility

About

In the present study the investigators compared the hormonal and metabolic effects of three meal loads very popular among Italian eating habits, both in the resting- and exercising state. Given the lack of time is considered a common barrier to exercise adherence, we wanted to identify a low dose of exercise capable to produce health benefits in the post-absorptive status elicited by three commonly consumed meal-models in Mediterranean countries. To this end, healthy young volunteers firstly underwent an oral glucose tolerance test (OGTT) and three meal tolerance tests. Secondly, in an extra set of experiments, subjects cycled at low intensity for the last 20 minutes of the same glucose/meal tolerance test. Glycemia, insulinemia, ghrelinemia, lipidemia, and satiety were measured throughout OGTT and each test-meal load.

Full description

The investigators evaluated postprandial responses (glucose, insulin, ghrelin, free fatty acids (FFA)) elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise were investigated. All subjects underwent a 50-g OGTT (A) and 3 test-meal loads: milk and cereals (B1); milk, apple and chocolate cream-filled sponge cake (B2); milk, bread, apple and hazelnut chocolate cream (B3). In the exercise trial, participants cycled for 20 minutes at 40% VO2max, 100 minutes after load ingestion.

Enrollment: 19 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age between 18 and 40 years
• normal body weight (BMI =18.5 - 24.9 according to NHLBI)
• stable diet

Exclusion criteria

• Diabetes, tipe 1 and 2 (ADA criteria)
• Glucose intolerance (ADA criteria)
• Dyslipidemia (ATP III according to NCEP)
• Metabolic syndrome

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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19 participants in 2 patient groups

Breakfast without exercise

Active Comparator group

Description:

Each subject of the same arm underwent 2 interventions: breakfast with/without exercise

Treatment:

Dietary Supplement: Breakfast

Breakfast with exercise

Experimental group

Description:

Each subject of the same arm underwent 2 interventions: breakfast with/without exercise

Treatment:

Dietary Supplement: Breakfast

Other: exercise