Metabolic and Molecular Responses Under the Effect of Taurine Supplementation With and Without Multicomponent Training

University of Sao Paulo

Status: Not yet enrolling

Conditions: Sarcopenic Obesity

Treatments: Other: Placebo (PL); Dietary Supplement: Taurine (Tau); Other: Placebo and Exercise (PL+Ex); Dietary Supplement: Taurine and Exercise (Tau+Ex)

Study type: Interventional

Funder types: Other

Identifiers

NCT05437952

taurine_training_metabolomics

Details and patient eligibility

About

Sarcopenic obesity is characterized by a progressive decline in muscle mass and an increase in body fat, a condition especially present in the elderly. A significant improvement in metabolic parameters has been observed with the completion of taurine supplementation and also with the practice of physical exercise, but there are no studies associating the interventions mentioned above with the aim of analyzing the metabolic profile of elderly people with sarcopenic obesity. The metabolomics approach allows the study of a whole set of metabolites involved in a biological system. It is believed that taurine supplementation associated with physical exercise is capable of promoting positive contributions to the metabolic profile, investigated through a metabolomics approach. Therefore, the present study seeks to investigate whether taurine supplementation associated with exercise is able to promote contributions to the metabolic profile, through a metabolomics approach, in elderly women with sarcopenic obesity.

Full description

Sarcopenic obesity is characterized by a progressive decline in muscle mass and an increase in body fat, a condition especially present in the elderly. A significant improvement in metabolic parameters has been observed with the completion of taurine supplementation and also with the practice of physical exercise, but there are no studies associating the interventions mentioned above with the aim of analyzing the metabolic profile of elderly people with sarcopenic obesity. The metabolomics approach allows the study of a whole set of metabolites involved in a biological system. It is believed that taurine supplementation associated with physical exercise is capable of promoting positive contributions to the metabolic profile, investigated through a metabolomics approach. The study will involve 60 elderly women with sarcopenic obesity who will be randomly distributed into 4 groups: 1) GPL, submitted to placebo supplementation (n=15); 2) GTAU, submitted to taurine supplementation (n=15); 3) GPL+EX, submitted to placebo supplementation associated with physical exercise (n=15) and 4) GTAU+EX, submitted to taurine supplementation associated with physical exercise (n=15). The interventions will take place for 16 weeks, collections and evaluations will be carried out pre and post-intervention of functional capacity testing, anthropometry, resting energy expenditure, biopsy of white adipose tissue for analysis of gene expression and blood collection for analysis of the plasma concentration of taurine and of the metabolomic profile. Body composition, and food consumption will be evaluated pre, during and post-intervention. The synergistic effects of the proposed intervention are expected to improve the metabolic parameters, regarding the profile anti-inflammatory, antioxidant, lipid metabolism, body composition, and functional physical capacity in elderly women with sarcopenic obesity.

Enrollment: 60 estimated patients

Sex: Female

Ages: 60 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI between 30 and 40kg/m²;
• Appendicular lean mass below 15 kg;
• Dynamometry below the cutoff point adjusted for sex and BMI (less than or equal to 21kg);
• "Sit and stand" test below the cut-off point adjusted for the age group, considering the number of repetitions in 30 seconds;
• Present medical certificate to perform physical exercise

Exclusion criteria

• alcoholics
• smokers;
• with any disease that prevents the practice of physical activity;
• medical impediment to the practice of physical exercise throughout the study;
• infectious diseases;
• coronary diseases;
• chronic kidney diseases;
• undergoing nutritional monitoring or weight loss treatment;
• score ≤13 for cognitive screening on the Mini-Mental State Examination (MMSE), suggested by Bertolucci et al. (1994).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 4 patient groups, including a placebo group

Taurine and Exercise (Tau+Ex)

Experimental group

Description:

Participants who will receive 3g of taurine supplementation associated with physical training in the period of 16 weeks.

Treatment:

Dietary Supplement: Taurine and Exercise (Tau+Ex)

Placebo and Exercise (PL+Ex)

Experimental group

Description:

Participants who will receive 3g of placebo supplementation associated with physical training in the period of 16 weeks.

Treatment:

Other: Placebo and Exercise (PL+Ex)

Taurine (Tau)

Experimental group

Description:

Participants who will receive 3g of taurine supplementation in the period of 16 weeks.

Treatment:

Dietary Supplement: Taurine (Tau)

Placebo (PL)

Placebo Comparator group

Description:

Participants who will receive 3g of placebo supplementation in the period of 16 weeks.

Treatment:

Other: Placebo (PL)