Metabolic and Neurofunctional Responses to Breakfasts

San Donato Group (GSD)

Status: Completed

Conditions: Attention Deficit and Disruptive Behavior Disorders; Lack of Satiety; Feeding Behaviors

Treatments: Dietary Supplement: Milk, apple & bread w/ cream; Dietary Supplement: Milk & Cereals; Dietary Supplement: Glucose; Device: EEG_pre; Device: EEG_post; Dietary Supplement: Milk, apple & snack

Study type: Interventional

Funder types: Other

Identifiers

NCT02897570

Colazioni/4

Details and patient eligibility

About

This study aims at assessing the effects of glucose and different types of breakfast on metabolic and neurofunctional responses in healthy individuals.

Twelve healthy subjects, on a stable diet, in a randomized-crossover fashion, received either a 50 g glucose load (control) or one of these breakfast:

B1: milk (125ml) and cereals (30g); B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g); B3: milk (125ml), bread (50g), apple (150g) and hazelnut cream chocolate (15g). Prior and upon completion of each tolerance test, an EEG was performed to measure frontal P300-evoked potentials.

Enrollment: 12 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18.5 - 24.9 kg/m2
• normal glucose tolerance
• stable diet

Exclusion criteria

• type 1 and type 2 diabetes
• impaired glucose tolerance
• dyslipidemia
• metabolic syndrome

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 4 patient groups

Glucose

Active Comparator group

Description:

EEG_pre + Oral glucose tolerance test (50-g OGTT) + EEG_post

Treatment:

Dietary Supplement: Glucose

Device: EEG_pre

Device: EEG_post

Milk + Cereals

Experimental group

Description:

EEG_pre + B1: milk (125ml) and cereals (30g) + EEG_post

Treatment:

Dietary Supplement: Milk, apple & snack

Dietary Supplement: Milk & Cereals

Device: EEG_pre

Device: EEG_post

Milk + Apple + Snack

Experimental group

Description:

EEG_pre + B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g) + EEG_post

Treatment:

Dietary Supplement: Milk & Cereals

Dietary Supplement: Milk, apple & bread w/ cream

Device: EEG_pre

Device: EEG_post

Milk + Apple + Bread w/ cream

Experimental group

Description:

EEG_pre + B3: milk (125ml), apple (150g), and bread (50g) with hazelnut chocolate cream (15g) + EEG_post

Treatment:

Dietary Supplement: Milk & Cereals

Dietary Supplement: Milk, apple & bread w/ cream

Device: EEG_pre

Device: EEG_post