Metabolic Availability of Lysine From White Maize

The Hospital for Sick Children

Status and phase: Completed; Phase 1

Conditions: Healthy Adults

Treatments: Dietary Supplement: Crystalline Lysine Amino Acid Mix; Dietary Supplement: White corn meal porridge

Study type: Interventional

Funder types: Other

Identifiers

NCT02018575

0019850580 amendment

Details and patient eligibility

About

Our objective is to determine the metabolic availability of Lysine in white maize using the indicator amino acid oxidation (IAAO) technique in adult men.

Full description

Our objective is to determine the metabolic availability of Lysine in white maize. 7 young, healthy, male adults will receive graded levels (29, 37,46 and 54%) of lysine requirement of 35 mg/kg/d as a crystalline AA mixture and a porridge of white cornmeal protein respectively.

Enrollment: 7 patients

Sex: Male

Ages: 20 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Adult males (20-49 years old)

Exclusion criteria

• A history of recent weight loss or illness
• Use of any medication at the time of entry into the study

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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7 participants in 1 patient group

levels of lysine intake.

Experimental group

Description:

Randomly selected levels of lysine intake which are lower than the lysine requirement (previously derived).

Treatment:

Dietary Supplement: Crystalline Lysine Amino Acid Mix

Dietary Supplement: White corn meal porridge