Metabolic Availability of Tryptophan From White Maize

The Hospital for Sick Children

Status: Completed

Conditions: Healthy

Treatments: Other: Tryptophan

Study type: Interventional

Funder types: Other

Identifiers

NCT02402179

1000048461

Details and patient eligibility

About

Our objective is to determine the metabolic availability of Tryptophan in white maize using the indicator amino acid oxidation (IAAO) technique in adult men.

Full description

Our objective is to determine the metabolic availability of Tryptophan in white maize. Seven young, healthy, male adults will receive graded levels (13.2, 26.4, 39.7, 52.9) of tryptophan requirement of 3.78 mg/kg/d as a crystalline amino acid (AA) mixture and a porridge of white cornmeal protein respectively.

Enrollment: 7 patients

Sex: Male

Ages: 20 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Adult males (20-49years old).
• Stable body weight
• Not on any medications that could affect protein and amino acid metabolism e.g. steroids.

Exclusion criteria

• Recent weight loss within the last 3 months or on weight reducing diet.
• Unwillingness to participate or unable to tolerate the diet.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

7 participants in 1 patient group

Tryptophan Amino Acid

Experimental group

Description:

13.2, 26.4, 39.7, 52.9% of the mean tryptophan requirement of 3.78 mg/kg/d will be given to subjects.

Treatment:

Other: Tryptophan