Metabolic Changes in Hypothyroid Patients

University of Aarhus

Status: Completed

Conditions: Hypothyroidism

Treatments: Drug: L-thyroxine

Study type: Interventional

Funder types: Other

Identifiers

NCT00524238

20030196

Details and patient eligibility

About

Hypothyroidism is a frequent condition in danish women, but often overlooked. Along with fatigue one of the main symptoms is weight gain as a result to significantly decreased energy expenditure.

This study was undertaken to elucidate changes in glucose, lipid and amino acid turnover in these patients.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Newly diagnosed hypothyroidism with tsh over 40 mU/L, etiology chronic autoimmune thyroiditis
• Healthy controls matched regarding sex, age and body mass index

Exclusion criteria

• Pregnancy, breastfeeding

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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22 participants in 2 patient groups

1

Other group

Description:

11 hypothyroid patients, newly diagnosed, examined before and after treatment

Treatment:

Drug: L-thyroxine

2

No Intervention group

Description:

10 healthy controls