Metabolic Characteristics of Type 2 Diabetes Mellitus Combined With Acute Myocardial Infarction: A Untargeted Metabolomics Study

Capital Medical University

Status: Completed

Conditions: STEMI

Treatments: Device: liquid chromatography-mass spectrometry (LC/MS) analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05601310

BFH-Metabolomics and STEMI

Details and patient eligibility

About

This study is a retrospective case-control study. In this study, through untargeted metabolomics, investigators identified several specific changed serum metabolites in T2DM patients with or without AMI and their functions/category. Moreover, researchers selected several endogenous candidate biomarkers with larger fold change for validation in expanded population to find biomarkers which effectively predict the development of STEMI in patients with T2DM.

Enrollment: 82 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• STEMI patients meet the diagnostic criteria of "Guidelines for the Diagnosis and Treatment of Acute ST-segment Elevation Myocardial Infarction (2015)".
• STMEI patients undergoing emergency PCI should undergo emergency PCI within 12 hours of onset at Beijing Friendship Hospital affiliated to Capital Medical University.
• All diabetic patients meet the diagnostic criteria for type 2 diabetes.
• They agreed to be enrolled in the trial and signed the informed consent.

Exclusion criteria

• Combined with severe valvular disease or congenital heart disease, hypertension, chronic kidney disease, stroke, hyperlipidemia, previous history of coronary artery disease.
• Involved in acute infection, severe hepatic dysfunction, tumor, rheumatic immune disease.
• Incomplete clinical information.

Trial design

82 participants in 3 patient groups

Control group

Description:

in the group, the participants exhibited negative results or \<50% obstruction upon coronary artery CT or coronary angiography. The group did not have coronary heart disease and diabetes

Treatment:

Device: liquid chromatography-mass spectrometry (LC/MS) analysis

T2DM group

Description:

in the group, the participants exhibited negative results or \<50% obstruction upon coronary artery CT or coronary angiography. The group did not have coronary heart disease but have type 2 diabetes mellitus.

Treatment:

Device: liquid chromatography-mass spectrometry (LC/MS) analysis

T2DM+AMI group

Description:

In the group, we eventually recruited 30 adult patients who were firstly diagnosed ST-elevation myocardial infarction (STEMI) within 12 hours of appearance chest pains or other AMI symptoms and had no previous history of coronary artery disease (CAD). Peripheral venous blood samples were drawn from subjects on admission or prior to coronary revascularization.

Treatment:

Device: liquid chromatography-mass spectrometry (LC/MS) analysis