Metabolic Cluster Analysis in Septic Shock Patients (ACMEcat)

Corporacion Parc Tauli

Status: Enrolling

Conditions: Septic Shock

Treatments: Other: Fluid challenge

Study type: Observational

Funder types: Other

Identifiers

NCT06500156

20235121

Details and patient eligibility

About

Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation. Hemodynamic and metabolic parameters before and after a fluid challenge (FC) will be measured.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion (elevated lactate and/or ScvO2 < 70%).

Exclusion criteria

• Age under 18 years old
• Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (> 10% from baseline dose) within the 15-minute period prior to, and/or during the administration of fluids.
• Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.

Trial design

120 participants in 1 patient group

Septic shock

Description:

Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion.

Treatment:

Other: Fluid challenge