Metabolic Consequences of Cross-sex Hormonal Treatment (DysGeMet)

Central Hospital, Nancy, France

Status: Unknown

Conditions: Gender Dysphoria

Treatments: Other: Gender-affirming hormone therapy

Study type: Observational

Funder types: Other

Identifiers

NCT04508231

2020PI157

Details and patient eligibility

About

Retrospective study in a single academic regional transgender referral center. Analyse VAT, body composition and metabolic parameters in non-obese transgender subjects one year after starting gender-affirming hormone therapy and in controls

Enrollment: 98 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (retrospective analysis of available data as a part of the regular care of subjects with gender dysphoria. All measurements were made at the time of the routine follow-up visits)

• age >= 16 years (Tanner stage IV) and <= 50 years at the initiation of gender-affirming hormone therapy;
• BMI < 28 kg/m2 at the initiation of cross-sex hormonal treatment.

Exclusion Criteria:

• hormonal contraception
• previous gender-affirming hormonal treatment
• previous gender-affirming surgery
• recognized syndrome or chromosomal defect, known metabolic or inflammatory disease, skeletal dysplasia, or chronic corticosteroid treatment.

Trial design

98 participants in 2 patient groups

Hormonal treatment

Description:

The University Hospital in Nancy is an academic regional transgender referral center in Lorraine (France) and keeps a register of subjects available from 2004. The register at the time of the present study (February 2020) included 320 subjects who met diagnostic criteria for gender dysphoria and were seen regularly in the out-patient clinic at our department of endocrinology. Our investigation is a part of the regular care of subjects with gender dysphoria.

Treatment:

Other: Gender-affirming hormone therapy

Controls

Description:

Data for control subjects are retrieved from medical records of healthy non-obese females and males who underwent an initial assessment for gender dysphoria in our department, but not yet receiving hormonal treatment at the time of the present study.