Metabolic Consequences of Moderate Weight Gain - Role of Dietary Fat Composition (LIPOGAIN)

Uppsala University

Status: Completed

Conditions: Healthy

Treatments: Other: Polyunsaturated fatty acid group; Other: Saturated fatty acid group

Study type: Interventional

Funder types: Other

Identifiers

NCT01427140

SLS-2011-LPG

Details and patient eligibility

About

The purpose of this study is to investigate the metabolic consequences of a moderate weight gain and if the type of dietary fat (saturated versus polyunsaturated) can modify the effects in young healthy adults. Hypothesis: the type of dietary fat can modify the effects of weight gain.

Full description

Specific goals:

• Investigate if dietary fat composition influences liver fat accumulation and metabolic risk factors in response to moderate weight gain
• Investigate if polyunsaturated fat (PUFA) in the diet could counteract any unfavorable metabolic changes that are expected to accompany moderate weight gain
• Investigate effects of weight gain and dietary fat composition on markers of vascular health

Enrollment: 41 patients

Sex: All

Ages: 20 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy,
• Body Mass Index 18-27

Exclusion criteria

• Liver disease,
• Coronary heart disease,
• Diabetes mellitus,
• Malignant diseases,
• Alcohol or drug abuse,
• Magnetic Resonance-incompatibility,
• Abnormal clinical chemistry,
• Use of drugs that significantly effects energy metabolism,
• Heavy exercise,
• Pregnancy or lactation,
• Allergy of gluten, egg or milk protein

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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41 participants in 2 patient groups

Saturated fatty acid group

Active Comparator group

Description:

Addition of saturated fatty acids to the diet inte the form of pastries

Treatment:

Other: Saturated fatty acid group

Polyunsaturated fatty acid group

Active Comparator group

Description:

Addition of polyunsaturated fatty acids to the diet in the form of pastries

Treatment:

Other: Polyunsaturated fatty acid group