Metabolic Disorders and Vertigo

I.M. Sechenov First Moscow State Medical University

Status: Unknown

Conditions: Vestibular Neuritis; Vestibular Migraine; Meniere Disease; Central Positional Vertigo; Benign Paroxysmal Positional Vertigo (BPPV)

Treatments: Diagnostic Test: diagnostic blood test; Diagnostic Test: neuropsychological test

Study type: Observational

Funder types: Other

Identifiers

NCT04935970

16-19

Details and patient eligibility

About

The purpose of investigation is to assess the levels of metabolic factors (hydroxyvitamin D, homocysteine) between patients with vestibular dysfunction of peripheral origin (BPPV) and central origin (vestibular migraine). Also we will analyse another factors (such as anxiety and depression) and optimize therapeuthical approach accordingly with the data.

Full description

Dizziness causes up to 2 to 15% of primary neurological complaints. In some patients who have undergone acute vertigo, postural instability, persistent postural perceptual vertigo (PPPV) develops, while in other similar cases occurs full recovery. So, it is necessary to search for neurophysiological, metabolic and psychophysiological factors and associated premorbid conditions that affect the outcome of neurovestibular compensation.

The case-control study will include 2 groups of patients suffering from vertigo of central and peripherial etiology. First group is recruited with patients were diagnosed with peripherial vestibular disorders, such as benign paroxysmal positional vertigo (BPPV), Meniere disease, vestibular neuritis. The proposal number of subjects in the first group is about forty. The second group will consist of forty patients with central vestibular disfunction: vestibular migraine, central positional vertigo etc. The inclusion of patient with persistent postural perceptual dizziness is discussed. Patients will be tested for hydroxyvitamin D and homocysteine in serum using an enzyme-linked immunosorbent assay (ELISA). The perception of the severity of disability was assessed using the Dizziness scale Handicap Inventory (DHI). All patients will undergo psychological test, including tas-26 scale, Beck's Depression Inventory, Spielberg-Hanin'sscale. Statistical analysis was carried out with the Statistical Analysis System (SAS) package. The relationships will be assessed using the chi squared test and logistic regression. The level of significance is set at p < 0.05. The methods for small samples (Mann-Whitney U ) will be used. It is presumed that differences in vitamin D levels beetween two groups will be considerable.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Written informed consent of participation in the study;
• Age:over 18 years old
• complaints of dizziness and insteadiness

Exclusion criteria

• Severe cognitive impairment (dementia)
• Severe depression
• Syncopal paroxysms
• Epileptic seizures
• Orthostatic hypotension
• Severe arrhythmia, unstable angina pectoris, acute myocardial infarction
• Pregnancy 8. Alcoholism, substance abuse and drug addiction
• Organic liver and kidney diseases with the development of functional disorders.
• Anemia (hemoglobin <10.5 g / dl for women and <11.5 g / dl for men)
• Active oncological process
• Demyelinating and neurodegenerative diseases.

Trial design

100 participants in 3 patient groups

patients with peripherial vestibular disorder

Description:

Forty patients with BPPV, vestibular neuritis or another peripherial vestibular disorder

Treatment:

Diagnostic Test: diagnostic blood test

Diagnostic Test: neuropsychological test

patients with central vestibular disorder

Description:

Forty patients vestibular disorder of central origin

Treatment:

Diagnostic Test: diagnostic blood test

Diagnostic Test: neuropsychological test

healthy controls

Description:

twenty healthy control without balance problems

Treatment:

Diagnostic Test: diagnostic blood test